Royal Air Force Typhoon fighter aircraft have operated alongside France's air force in a combined operation against an underground arms cache in Syria used by the IS group, according to the UK Ministry of Defence.
The location, identified by intelligence, was assessed as storing arms and explosives, the release indicated, and was located in hills just north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to hit a number of access tunnels down to the facility... early reports suggest the target was engaged successfully," the ministry announced.
There was no evidence of any harm to civilians in the strike late on Saturday and every plane involved returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - referred to as ISIS - enforced jihadist rule over parts of both Syria and Iraq prior to its 2019 collapse.
"This operation underscores our UK leadership, and determination to work closely with our allies, to eradicate any revival of IS and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary said.
British military aircraft have conducted patrols over Syria to "forestall any attempted resurgence" of IS following its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces participating in this mission for their skill and their courage," he said. "Including them were thousands of UK service members deployed over Christmas and New Year. This operation, to eliminate militants who pose a risk to our safety, demonstrates how our armed forces are ready to step up, all year round, protecting the UK domestically and strong abroad."
During December, the US military carried out what it called a "large-scale strike" against Daesh sites in Syria, following an ambush claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The UN reports Daesh still has an estimated 5,000 to 7,000 combatants in both countries.